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Publications
Our senior management has published over 200 scientific communications
in the field of analgesia and rheumatology. We have been invited
to provide scientific presentations in analgesia and rheumatology
drug development in the U.S. and in Europe at a variety of the
most prestigious and attended venues.
| Najib Babul | Donald
R. Mehlisch |
Najib Babul, PharmD (Selected Abstracts
and Publications)
| 1. |
Extended-release opioids for the management of chronic non-malignant pain. Expert Opinion on Drug Delivery 2006;3:489-97. |
| 2. |
Postsurgical Safety of Opioid-sparing Cyclooxygenase-2 Inhibitors. Anesthesiology 2006;104:375 |
| 3. |
Safety of Cox-2 Selective Nonsteroidal Antiinflammatory Drugs for Postsurgical Pain. Anesthesia and Analgesia 2006;102:644–56. |
| 4. |
Oxymorphone Extended-Release Tablets Relieve Moderate to Severe Pain and Improve Physical Function in Osteoarthritis: Results of a Randomized, Double-blind, Placebo-and Active-controlled Phase III Trial. Pain Medicine 2005;6:357-66. |
| 5. |
Efficacy and Safety of Extended Release Once Daily Tramadol in Chronic Pain: A Randomized 12-Week Clinical Trial in Osteoarthritis of the Knee. Journal of Pain and Symptom Management 2004;28:59-71. |
| 6. |
Efficacy of Oxymorphone Extended Release in Postsurgical Pain: A Randomized Clinical Trial in Knee Arthroplasty. Journal of Clinical Pharmacology, 2004; 44:767-776. |
| 7. |
Analgesic Efficacy of Inhaled Morphine in Patients Following Outpatient Orthopedic Surgery. Anesthesiology 2003;99:693-700. |
| 8. |
Morphine Nasal Solution Provides Analgesic Efficacy Superior to Placebo and Comparable to Intravenous Morphine: Results of a Randomized, Double-Blind, Placebo-Controlled, Clinical Trial in Moderate to Severe Post-surgical Pain. American Society of Anesthesiologists Annual Meeting, October 11-15, 2003, San Francisco, California. |
| 9. |
Chronic Pain Sleep Inventory for Evaluation of Treatment Responses to Opioid Analgesics: Randomized, Placebo Controlled Clinical Trials in OA. American Pain Society 22nd Annual Scientific Meeting, March 20-23, 2003, Chicago, Illinois. |
| 10. |
Patient and pain-related characteristics in randomized clinical trials in cancer pain. One-hundred and Third Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics, March 24-27, 2002, Atlanta, Georgia. |
| 11. |
Response characteristics of commonly used pharmacologic agents in neuropathic pain. One-hundred and Third Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics, March 24-27, 2002, Atlanta, Georgia. |
| 12. |
Efficacy and Safety of a Once-Daily Morphine Formulation in Chronic, Moderate-to-Severe Osteoarthritis Pain: Results from a Randomized, Placebo-Controlled, Double-Blind Trial and an Open-Label Extension Trial. Journal of Pain and Symptom Management 2002;23:278-91. |
| 13. |
Double blind randomized placebo control trial of controlled-release codeine in the treatment of osteoarthritis of the hip or knee. Journal of Rheumatology 2000;27:764-71. |
| 14. |
Randomized double-blind crossover trial comparing the safety and efficacy of oral controlled release oxycodone with controlled release morphine in patients with cancer pain. Journal of Clinical Oncology 1998;16:3222-3229. |
| 15. |
Efficacy of oxycodone in neuropathic pain: A randomized trial in postherpetic neuralgia. Neurology 1998;50:1837-41. |
| 16. |
Comparative efficacy and safety of controlled release morphine suppositories and tablets in cancer pain. Journal of Clinical Pharmacology 1998;38:74-81. |
| 17. |
Comparative clinical efficacy and safety of a novel controlled-release oxycodone formulation and controlled-release hydromorphone in the treatment of cancer pain. Cancer 1997; 79:1428-37. |
| 18. |
Randomised trial of oral morphine for painful episodes of sickle-cell disease in children. Lancet 1997; 350:1358-61. |
| 19. |
Hydromorphone and metabolite pharmacokinetics in children. Journal of Pain and Symptom Management 1995;10;335-37. |
| 20. |
Hydromorphone metabolite accumulation in renal failure. Journal of Pain and Symptom Management 1995;10:184-86. |
| 21. |
Steady-state pharmacokinetics of a novel, controlled release morphine suppository and subcutaneous morphine in cancer pain. Journal of Clinical Pharmacology 1995;35:666-72. |
| 22. |
Clinical efficacy and safety of a novel controlled release suppository and subcutaneous morphine in cancer pain. Journal of Clinical Oncology 1995;13:1520-27. |
| 23. |
Randomized evaluation of controlled release codeine and placebo in chronic cancer pain. Journal of Clinical Pharmacology 1995;10:612-23. |
| 24. |
Efficacy of controlled release codeine in chronic nonmalignant pain: A randomized, placebo controlled trial. Pain 1995;62:169-78. |
| 25. |
Clinical pharmacokinetics of hydromorphone and hydromorphone-3-glucuronide at steady-state following immediate and controlled release hydromorphone administration to cancer patients. Journal of Clinical Pharmacology 1995;35:38-45. |
| 26. |
Comparative clinical efficacy and safety of immediate and controlled release hydromorphone formulations in severe cancer pain. Cancer 1994;74:1808-16. |
| 27. |
Evaluation and use of opioid analgesics in pediatric cancer pain. Journal of Palliative Care 1993;9:19-25. |
| 28. |
Disposition of morphine and its glucuronide metabolites after oral and rectal administration: Evidence of route specificity. Clinical Pharmacology and Therapeutics 1993;54:286-92. |
| 29. |
Using memory for pain in analgesic research. The Annals of Pharmacotherapy 1993;27:9-12. |
| 30. |
Pharmacokinetics of two novel rectal controlled release morphine formulations. Journal of Pain and Symptom Management 1992;7:400-405. |
| 30. |
Putative role of hydromorphone metabolites in myoclonus. Pain 1992;51:260-61. |
| |
 |
Donald R. Mehlisch, MD, DDS (Selected Abstracts and Publications)
| 1. |
The time to onset and overall analgesic efficacy of rofecoxib 50 mg: a meta-analysis of 13 randomized clinical trials. Clin J Pain. 2005;21:241-50. |
| 2. |
The analgesic efficacy of intramuscular parecoxib sodium in postoperative dental pain. J Am Dent Assoc. 2004;135:1578-90. |
| 3. |
Single doses of parecoxib sodium intravenously are as effective as ketorolac in reducing pain after oral surgery. J Oral Maxillofac Surg. 2003;61(9):1030-7. |
| 4. |
Comparisons Between Dental and Non-Dental Model Responses
To Predict a Non-Dental Model Response. American Pain Society,
22nd Annual Scientific Meeting, Chicago, Illinois, March 20-23,
2003. |
| 5. |
Comparison of the Analgesic Efficacy of Rofecoxib 50 mg and
Placebo in Acute Pain: A Combined Analysis of 13 Clinical Studies.
American Pain Society, 22nd Annual Scientific Meeting, Chicago,
Illinois, March 20-23, 2003. |
| 6. |
Placebo TOTPAR Scores As An Indicator of Model Sensitivity
in Acute Pain. American Pain Society, 19th Annual Scientific
Meeting, Atlanta, Georgia, November 2-5, 2000. |
| 7. |
The Dental Model As An Indicator for Non-Dental Model Response.
American Pain Society, 19th Annual Scientific Meeting, Atlanta,
Georgia, November 2-5, 2000 |
| 8. |
Pharmacologic Response to Single Entity Opioids in Post-Operative
Dental Pain. American Pain Society, 19th Annual Scientific
Meeting, Atlanta, Georgia, November 2-5, 2000. |
| 9. |
Very Low Dose Naltrexone and Gender Modify Morphine Analgesia
in Patients with Post-Operative Pain. American Pain Society,
19th Annual Scientific Meeting, Atlanta, Georgia, November
2-5, 2000. |
| 10. |
Placebo TOTPAR Scores As An Indicator of Model Sensitivity
in Acute Pain. American Society of Clinical Pharmacology and
Therapeutics, 101st Annual Meeting, Los Angeles, California,
March 15-17, 2000. |
| 11. |
Correlation of Pharmacokinetics with Onset and Duration of
Analgesia of Intramuscular Doses of Parecoxib in Postoperative
Dental Pain. American Society of Clinical Pharmacology and
Therapeutics, 101st Annual Meeting, Los Angeles, California,
March 15-17, 2000. |
| 12. |
Pharmacokinetic and Efficacy Evaluation of Intravenous Parecoxib
In A Postsurgical Dental Pain Model. American Society of Clinical
Pharmacology and Therapeutics, 101st Annual Meeting, Los Angeles,
California, March 15-17, 2000. |
| 13. |
Oxaprozin Potassium Compared with Oxycodone/Acetaminophen
for Management of Post-Operative Pain. American Pain Society,
18th Annual Scientific Meeting, Ft. Lauderdale, Florida, October
21-24, 1999. |
| 14. |
Oxaprozin Potassium, Sumatriptan, and Placebo in Patients
with Moderate or Severe Acute Migraine Headache. American Pain
Society, 18th Annual Scientific Meeting, Ft. Lauderdale, Florida,
October 21-24, 1999. |
| 15. |
Analgesic Efficacy of New Controlled Released Acetaminophen
Sprinkles, Marketed APAP Extended Relief Caplets and Placebo
in Post-Operative Dental Pain. American Pain Society, 17th
Annual Scientific Meeting, San Diego, California, November
5-8, 1998. |
| 16. |
Letters to the Editor: The Combination of Low Dose of Naloxone
and Morphine in Patient-Controlled (PCA) Does Not Decrease
Opioid Requirements in the Postoperative Period. Pain. 2003;101
(1-2): 209-212. |
| 17. |
A Controlled Comparative Study of Ibuprofen Arginate Versus
Conventional Ibuprofen in the Treatment of Postoperative Dental
Pain. Journal Clinical Pharmacology. 2002; 42(8):904-911. |
| 18. |
Efficacy of Combination Analgesic Therapy in Relieving Dental
Pain. Journal of American Dental Association. 2002;133(7):861-871. |
| 19. |
Efficacy and Tolerability of the Specific Cyclooxygenace-2
Inhibitor DFP Compared with Naproxen Sodium in Patients with
Postoperative Dental Pain. Clinical Therapeutics. 1999;21(8):1301-12. |
| 20. |
The Efficacy of Nonsteroidal Anti- Inflammatory Drugs for
Acute Pain. Cancer Control. 1999 Mar-Apr;6(2 Suppl 1):5-9. |
| 21. |
Characterization of rofecoxib as a cyclooxygenase-2 isoform
inhibitor and demonstration of analgesia in the dental pain
model. Clinical Pharmacology & Therapeutics. 1999;65(3):336-347. |
| 22. |
Ketoprofen, Acetaminophen, and Placebo in The Treatment of
Tension Headache. Headache. 1998;38:579-589. |
| 23. |
Comparison of Bromfenac and Naproxen Sodium in the Management
of Primary Dysmenorrhea. Primary Care Update Ob Gyn. 1998;1(5):195. |
| 24. |
Double-Blind, Single-Dose Comparison of Bromfenac Sodium,
Tramadol, and Placebo after Oral Surgery. The Journal of Clinical
Pharmacology. 1998;38(5):455-462. |
| 25. |
Recent Studies of Bromfenac Sodium in Oral Surgery. The American
Journal of Orthopedics. 1998;27 (4S):17-21. |
| 26. |
A Crossover Comparison of Bromfenac Sodium, Naproxen Sodium,
and Placebo for Relief of Pain from Primary Dysmenorrhea. Journal
of Women's Health. 1997;6(1):83-92. |
| 27. |
SC-548635, a highly selective inhibitor of COX-2, is an effective
analgesic in an acute post-surgical pain model. Invest Med
1996;44(3): 293A |
| 28. |
Comparative Study of Ibuprofen Lysine and Acetaminophen in
Patients with Postoperative Dental Pain. Clinical Therapeutics.
1995;17(5):852-860. |
| 29. |
Multicenter Clinical Trial of Ibuprofen and Acetaminophen
in the Treatment of Postoperative Dental Pain. Journal of American
Dental Association. 1990; 121:257-263. |
| 30. |
Double-Blind Crossover Comparison of Ketoprofen, Naproxen,
and Placebo in Patients with Primary Dysmenorrhea. Clinical
Therapeutics. 1990;12(5):398-409. |
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